A human Y-linked DNA polymorphism and its potential for estimating genetic and evolutionary distance.

@article{Casanova1985AHY,
  title={A human Y-linked DNA polymorphism and its potential for estimating genetic and evolutionary distance.},
  author={Myriam Casanova and Philippe Leroy and C Boucekkine and Jean Weissenbach and Colin Bishop and M. Fellous and Michele Purrello and Ginevra Fiori and Marcello Siniscalco},
  journal={Science},
  year={1985},
  volume={230 4732},
  pages={1403-6}
}
A human DNA sequence (p12f2), derived from a partial Y-chromosome genomic library and showing homology with the X and Y chromosomes and with an undetermined number of autosomes, detected two Y-specific restriction fragment length variants on male DNA that had been digested with Taq I and Eco RI. These variants may have been generated through a deletion-insertion mechanism and their pattern of holoandric transmission indicates that they represent a two-allele Y-linked polymorphism (RFLP). By… CONTINUE READING

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