A human TATA binding protein-related protein with altered DNA binding specificity inhibits transcription from multiple promoters and activators.

@article{Moore1999AHT,
  title={A human TATA binding protein-related protein with altered DNA binding specificity inhibits transcription from multiple promoters and activators.},
  author={Paul A. Moore and Josef Ozer and M Salunek and Gw{\'e}na{\"e}l Jan and D Zerby and Susan Mary Campbell and Paul M. Lieberman},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 11},
  pages={7610-20}
}
The TATA binding protein (TBP) plays a central role in eukaryotic and archael transcription initiation. We describe the isolation of a novel 23-kDa human protein that displays 41% identity to TBP and is expressed in most human tissue. Recombinant TBP-related protein (TRP) displayed barely detectable binding to consensus TATA box sequences but bound with slightly higher affinities to nonconsensus TATA sequences. TRP did not substitute for TBP in transcription reactions in vitro. However… CONTINUE READING
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