A human T cell-specific molecule is a member of a new gene family.

  title={A human T cell-specific molecule is a member of a new gene family.},
  author={Thomas J. Schall and Jan Jongstra and Barbara J. Dyer and Joakim Jorgensen and Carol A. Clayberger and M. M. Davis and Alan M. Krensky},
  journal={Journal of immunology},
  volume={141 3},
We have used a cDNA library enriched for T cell-specific sequences to isolate genes expressed by T cells but not by other cell types. We report here one such gene, designated RANTES, which encodes a novel T cell-specific molecule. The RANTES gene product is predicted to be 10 kDa and, after cleavage of the signal peptide, approximately 8 kDa. Of the 68 residues, 4 are cysteines, and there are no sites for N-linked glycosylation. RANTES is expressed by cultured T cell lines that are Ag specific… CONTINUE READING
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