A human Mad protein acting as a BMP-regulated transcriptional activator

@article{Liu1996AHM,
  title={A human Mad protein acting as a BMP-regulated transcriptional activator},
  author={Fang Liu and Akiko Hata and Julie C. Baker and Jacqueline Doody and Juan C{\'a}rcamo and Richard M Harland and Joan Massagu{\'e}},
  journal={Nature},
  year={1996},
  volume={381},
  pages={620-623}
}
THE TGF-β/activin/BMP cytokine family signals through serine/threonine kinase receptors, but how the receptors transduce the signal is unknown. The Mad (Mothers against decapentaplegic) gene from Drosophila1 and the related Sma genes from Caenorhabditis elegans2 have been genetically implicated in signalling by members of the bone-morphogenetic-protein (BMP) subfamily. We have cloned Smad1, a human homologue of Mad and Sma. Microinjection of Smad1 messenger RNA into Xenopus embryo animal caps… CONTINUE READING
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