A human HAP1 homologue. Cloning, expression, and interaction with huntingtin.

@article{Li1998AHH,
  title={A human HAP1 homologue. Cloning, expression, and interaction with huntingtin.},
  author={Shihua Li and Seyed Hossein Hosseini and Claire-Anne Gutekunst and Steven M. Hersch and Robert Ferrante and Xshang Li},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 30},
  pages={19220-7}
}
Huntington's disease (HD) is caused by the expansion of a glutamine repeat in the protein huntingtin. The expanded glutamine repeat is thought to mediate a gain of function by causing huntingtin to abnormally interact with other proteins. We previously identified a rat huntingtin-associated protein (HAP1) that binds to huntingtin; HAP1 binds more tightly to huntingtin with an expanded glutamine repeat than to wild type huntingtin. Identification of the human homologue of HAP1 is necessary for… CONTINUE READING

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