A human H19 transgene exhibits impaired paternal-specific imprint acquisition and maintenance in mice.

@article{Jones2002AHH,
  title={A human H19 transgene exhibits impaired paternal-specific imprint acquisition and maintenance in mice.},
  author={Beverly K. Jones and John M. Levorse and Shirley Marie Tilghman},
  journal={Human molecular genetics},
  year={2002},
  volume={11 4},
  pages={
          411-8
        }
}
Genomic imprinting, the differential expression of autosomal genes based on their parent of origin, is observed in all eutherian mammals that have been examined. In most instances the genes that are imprinted in one species are imprinted in others as well, suggesting that imprinting predated eutherian radiation. For example, the RNA-coding H19 gene is repressed upon paternal inheritance in all species examined to date. Thus, it is surprising that there is remarkably little sequence conservation… CONTINUE READING

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