A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest.

@article{Yuasa2006AHD,
  title={A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest.},
  author={Mayumi S Yuasa and Chikahide Masutani and Akihiko Hirano and Martin A. Cohn and Masaru Yamaizumi and Yoshihiro Nakatani and Fumio Hanaoka},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2006},
  volume={11 7},
  pages={731-44}
}
DNA polymerase eta (Poleta) is responsible for efficient translesion synthesis (TLS) past cis-syn cyclobutane thymine dimers (TT dimers), the major DNA lesions induced by UV irradiation. Loss of human Poleta leads to xeroderma pigmentosum variant syndrome, clearly indicating that Poleta plays a vital role in preventing skin cancer caused by exposure to sunlight. To further examine Poleta functions and the mechanisms that regulate this important protein, Poleta complexes were purified from HeLa… CONTINUE READING

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