A human CD34(+) subset resides in lymph nodes and differentiates into CD56bright natural killer cells.

@article{Freud2005AHC,
  title={A human CD34(+) subset resides in lymph nodes and differentiates into CD56bright natural killer cells.},
  author={Aharon G. Freud and Brian Becknell and Sameek Roychowdhury and Hsiaoyin Charlene Mao and Amy K. Ferketich and Gerard J Nuovo and Tiffany Hughes and Trent B Marburger and John J. Sung and Robert A Baiocchi and Martin Guimond and Michael A. Caligiuri},
  journal={Immunity},
  year={2005},
  volume={22 3},
  pages={295-304}
}
In humans, T cells differentiate in thymus and B cells develop in bone marrow (BM), but the natural killer (NK) precursor cell(s) and site(s) of NK development are unclear. The CD56bright NK subset predominates in lymph nodes (LN) and produces abundant cytokines compared to the cytolytic CD56dim NK cell that predominates in blood. Here, we identify a novel CD34dimCD45RA(+) hematopoietic precursor cell (HPC) that is integrin alpha4beta7bright. CD34dimCD45RA(+)beta7bright HPCs constitute <1% of… CONTINUE READING

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