A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

@article{Ledesma2009AH5,
  title={A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage},
  author={Felipe Cortes Ledesma and Sherif F. El Khamisy and Maria C C Zuma and Kay Osborn and Keith W. Caldecott},
  journal={Nature},
  year={2009},
  volume={461},
  pages={674-678}
}
Topoisomerases regulate DNA topology and are fundamental to many aspects of chromosome metabolism. Their activity involves the transient cleavage of DNA, which, if it occurs near sites of endogenous DNA damage or in the presence of topoisomerase poisons, can result in abortive topoisomerase-induced DNA strand breaks. These breaks feature covalent linkage of the enzyme to the DNA termini by a 3′- or 5′-phosphotyrosyl bond and are implicated in hereditary human disease, chromosomal instability… CONTINUE READING
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