A human 3' miR-499 mutation alters cardiac mRNA targeting and function.


RATIONALE MyomiRs miR-499, miR-208a and miR-208b direct cardiac myosin gene expression. Sequence complementarity between miRs and their mRNA targets determines miR effects, but the functional consequences of human myomiR sequence variants are unknown. OBJECTIVE To identify and investigate mutations in human myomiRs in order to better understand how and to… (More)
DOI: 10.1161/CIRCRESAHA.111.260752


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