A human, compact, fully functional anti-ErbB2 antibody as a novel antitumour agent

@article{Lorenzo2004AHC,
  title={A human, compact, fully functional anti-ErbB2 antibody as a novel antitumour agent},
  author={Claudia De Lorenzo and Andrea Tedesco and Giuseppe Terrazzano and Rosanna Cozzolino and Paolo Laccetti and Roberto Piccoli and G D'alessio},
  journal={British Journal of Cancer},
  year={2004},
  volume={91},
  pages={1200 - 1204}
}
A new human, compact antibody was engineered by fusion of a human, antitumour ErbB2-directed scFv with a human IgG1 Fc domain. Overexpression of the ErbB2 receptor is related to tumour aggressiveness and poor prognosis. This new immunoagent meets all criteria for a potential anticancer drug: it is human, hence poorly or not immunogenic; it binds selectively and with high affinity to target cells, on which it exerts an effective and selective antiproliferative action, including both antibody… CONTINUE READING

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