A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis

  title={A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis},
  author={Tom Moss and Fr{\'e}d{\'e}ric Langlois and Th{\'e}r{\`e}se Gagnon-Kugler and Victor Y. Stefanovsky},
  journal={Cellular and Molecular Life Sciences},
Ribosome biogenesis centres both physically and functionally on the activity of the ribosomal RNA (rRNA) genes. Ribosome assembly occurs co-transcriptionally on these genes, requires the coordinated expression and assembly of many hundreds of proteins and is finely tuned to cell and organism growth. This review presents contemporary understanding of the mode and the means of rRNA gene transcription and how growth factors, oncogenes and tumour suppressors regulate this transcription. It is… CONTINUE READING


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