A hotspot in the glucocorticoid receptor DNA-binding domain susceptible to loss of function mutation.

@article{Banuelos2015AHI,
  title={A hotspot in the glucocorticoid receptor DNA-binding domain susceptible to loss of function mutation.},
  author={Jesus Banuelos and Soon Cheon Shin and Nick Z Lu},
  journal={Steroids},
  year={2015},
  volume={96},
  pages={115-20}
}
Glucocorticoids (GCs) are used to treat a variety of inflammatory disorders and certain cancers. However, GC resistance occurs in subsets of patients. We found that EL4 cells, a GC-resistant mouse thymoma cell line, harbored a point mutation in their GC receptor (GR) gene, resulting in the substitution of arginine 493 by a cysteine in the second zinc finger… CONTINUE READING