A host susceptibility gene, DR1, facilitates influenza A virus replication by suppressing host innate immunity and enhancing viral RNA replication.

@article{Hsu2015AHS,
  title={A host susceptibility gene, DR1, facilitates influenza A virus replication by suppressing host innate immunity and enhancing viral RNA replication.},
  author={Shih-Feng Hsu and Wen-Chi Su and King-Song Jeng and Michael M C Lai},
  journal={Journal of virology},
  year={2015},
  volume={89 7},
  pages={3671-82}
}
UNLABELLED Influenza A virus (IAV) depends on cellular factors to complete its replication cycle; thus, investigation of the factors utilized by IAV may facilitate antiviral drug development. To this end, a cellular transcriptional repressor, DR1, was identified from a genome-wide RNA interference (RNAi) screen. Knockdown (KD) of DR1 resulted in reductions… CONTINUE READING