A host Ca2+/Mn2+ ion pump is a factor in the emergence of viral RNA recombinants.

@article{Jaag2010AHC,
  title={A host Ca2+/Mn2+ ion pump is a factor in the emergence of viral RNA recombinants.},
  author={Hannah Miriam Jaag and Judit Pogany and Peter D Nagy},
  journal={Cell host & microbe},
  year={2010},
  volume={7 1},
  pages={74-81}
}
Viruses change rapidly due to genetic mutations, and viral RNA recombination in RNA viruses can lead to the emergence of drug-resistant or highly virulent strains. Here, we report that host Pmr1p, an ion pump that controls Ca2+/Mn2+ influx into the Golgi from the cytosol, affects the frequency of viral RNA recombination and the efficiency of replication. Inactivation of PMR1 leads to an approximately 160-fold increase in RNA recombination of Tomato bushy stunt virus (TBSV) in yeast, a model… CONTINUE READING

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