A horizontal slice preparation for examining the functional connectivity of dorsal column fibres in mouse spinal cord.

@article{Flynn2011AHS,
  title={A horizontal slice preparation for examining the functional connectivity of dorsal column fibres in mouse spinal cord.},
  author={Jamie R. Flynn and Alan M. Brichta and Mary Pauline Galea and Robert John Callister and Brett Anthony Graham},
  journal={Journal of neuroscience methods},
  year={2011},
  volume={200 2},
  pages={113-20}
}
In spinal cord injury (SCI) research, axon regeneration across spinal lesions is most often assessed using anatomical methods. It would be extremely advantageous, however, to examine the functional synaptic connectivity of regenerating fibres, using high-resolution electrophysiological methods. We have therefore developed a mouse horizontal spinal cord slice preparation that permits detailed analysis of evoked dorsal column (DCol) synaptic inputs on spinal neurons, using whole-cell patch clamp… CONTINUE READING
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