A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC.

@article{Beck1992AHO,
  title={A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC.},
  author={Sebastian Beck and Isabel Hanson and Adrian Kelly and Darryl J. Pappin and John Trowsdale},
  journal={DNA sequence : the journal of DNA sequencing and mapping},
  year={1992},
  volume={2 4},
  pages={203-10}
}
The RING3 gene maps in the class II region of the human major histocompatibility complex, at a CpG island distal of the HLA-DNA gene. RING3 cDNAs were obtained from a T cell cDNA library and the longest (4 kb) was sequenced. The sequence contained an open reading frame encoding a protein of 754 amino acids. A screen of protein databases revealed striking homology between the RING3 protein and the Drosophila female sterile homeotic gene (fsh) which is implicated in the establishment of segments… CONTINUE READING