A homologous protein-coding sequence in drosophila homeotic genes and its conservation in other metazoans

@article{McGinnis1984AHP,
  title={A homologous protein-coding sequence in drosophila homeotic genes and its conservation in other metazoans},
  author={William McGinnis and Richard L. Garber and Johannes Wirz and Atsushi Kuroiwa and W. J. Gehring},
  journal={Cell},
  year={1984},
  volume={37},
  pages={403-408}
}
The homeotic genes of the bithorax complex (BX-C) and the Antennapedia complex (ANT-C) of Drosophila appear to specify the developmental fate of segments or parts of segments of the fly. We have previously reported weak DNA sequence homology between 3' portions of the Antennapedia and fushi tarazu genes of the ANT-C and the Ultrabithorax gene of the BX-C. Here we show that this DNA homology (the homeo box) is due to a conserved protein-coding sequence present in these three pattern-formation… Expand
Evolutionary Analysis of Mammalian Homeobox Genes
TLDR
The homeobox was first discovered as a common DNA sequence element in homeotic genes of the fruit fly Drosophila melanogaster and it is intriguing to note that the linear order of the genes on the chromosome in these complexes is collinear with the gradient of expression of homeotic gene products along the anterior-posterior axis in the embryo. Expand
Murine Homeo-Genes: Some Aspects of their Organisation and Structure
TLDR
Organisational features apparent at both levels may provide insight into their evolution, phylogenetic relationships, and possible modes of action in vertebrate morphogenesis, pattern formation and the specification of cell lineages. Expand
Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes
TLDR
Experiments are described which show that two homoeo box loci map, respectively, to evolutionarily related regions on mouse chromosome 11 and human chromosome 17. Expand
A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene
TLDR
A new subfamily of evolutionarily conserved nuclear and possibly DNA-binding proteins that again relate to a Drosophila segmentation gene as in the case of the homeo domain is demonstrated. Expand
Homeo box gene complex on mouse chromosome 11: Molecular cloning, expression in embryogenesis, and homology to a human homeo box locus
TLDR
Cloned three overlapping recombinant phage clones that cover a region of mouse chromosome 11 that contains a cluster of four homeo boxes encodes multiple transcripts that are expressed during embryogenesis provide direct evidence for genetic expression during embryonic development and a conserved organization in comparison to the cognate human locus. Expand
Murine Hox genes--a multigene family.
TLDR
It was hypothesized that the Drosophila homeodomain proteins might also have regulatory functions, e.g., by interacting directly or indirectly in trans with their own promoter regions or those of other genes (Desplan et al. 1985). Expand
Temporal and Cellular Specificity of Expression of the Murine Homeobox-Containing Gene Hox-1.4
The homeobox is a 183 bp DNA sequence which was originally identified in Drosophila genes that are important in development. Its conservation in the genomes of diverse groups of animals, includingExpand
Molecular characterization of TgHBox4, a Drosophila Abd-B homolog found in the sea urchin Tripneustes gratilla.
TLDR
A cDNA clone that encodes a sea urchin homolog of the homeobox containing the gene Abdominal-B of Drosophila is isolated and sequenced, indicating that TgHBox4 is probably not involved in pattern formation but may have a posterior-defining role late in embryogenesis. Expand
Homeo box genes and animal development
TLDR
Comparison of specific Drosophila and mouse gene homeo box gene sequences shows that some of the individual genes in the two species are truly homologues in terms of structure, i.e., individualHomeo box genes had evolved conserved and separate functions before the evolutionary divergence that eventually gave rise to arthropods and mammals. Expand
A mouse homologue of the Drosophila tumour-suppressor gene l(2)gl controlled by Hox-C8 in vivo
TLDR
Several candidate Hox gene targets are identified, including a mouse homologue of the Drosophila tumour-suppressor gene l(2)gl, by immunopurification of DNA sequences bound to a Hox protein in native chromatin. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 30 REFERENCES
Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila.
TLDR
Using a combination of chromosome walking and jumping, a DNA region from Drosophila containing Antennapedia is cloned, and the unusual size and complexity of this locus are discussed. Expand
Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes
A Xenopus laevis gene was cloned on the basis of cross-homology to a region conserved between several Drosophila homeotic genes. It was shown to be expressed during early development, starting atExpand
Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila
TLDR
In situ hybridization of an Antp+ cDNA probe to tissue sections of embryos, it is found that the neural cells of the transformed segments accumulateAntp+ transcripts to a level characteristic of the normal mesothorax. Expand
Defects in embryogenesis in mutants associated with the antennapedia gene complex of Drosophila melanogaster.
TLDR
It is concluded that mutations and deficiencies of genes associated with the ANT-C have profound effects on embryogenesis. Expand
Cloning and transcriptional analysis of the segmentation gene fushi tarazu of Drosophila
TLDR
The ftz gene encodes a single 1.9 kb poly(A)+ RNA expressed exclusively from the early blastoderm to gastrula stages of embryonic development and has been analyzed by S1 nuclease mapping and by restriction mapping of a cDNA clone. Expand
The molecular organization of the Antennapedia locus of drosophila
The Antennapedia complex (ANT-C) of Drosophila is a cluster of genes involved in the regulation of morphogenesis, including at least three homoeotic loci (Antp, Scr, and pb), in which mutations causeExpand
A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes
A repetitive DNA sequence has been identified in the Drosophila melanogaster genome that appears to be localized specifically within genes of the bithorax and Antennapedia complexes that are requiredExpand
A homoeotic mutation transforming leg to antenna in Drosophila
TLDR
The isolation and characterization of apparent null alleles of the Antp locus lead to a homoeotic phenotype which is the reverse of the dominant Antennapedia phenotype, namely, they result in the transformation of the second leg into an antenna but do not alter the development of the normal antenna itself. Expand
Molecular Genetics of the Bithorax Complex in Drosophila melanogaster
TLDR
The DNA of the bithorax complex has been isolated, and a region of 195,000 base pairs that covers the left half of the complex is described here. Expand
Spatial distribution of Antennapedia transcripts during Drosophila development.
TLDR
In third‐instar larvae, hybridization to the different imaginal disks of all three thoracic segments is observed, localized mainly to those regions that will form proximal, cuticular portions of the respective segments. Expand
...
1
2
3
...