A homolog of Drosophila grainy head is essential for epidermal integrity in mice.

@article{Ting2005AHO,
  title={A homolog of Drosophila grainy head is essential for epidermal integrity in mice.},
  author={S. B. Ting and Jacinta Caddy and Nikki Rochelle Hislop and Tomasz Wilanowski and Alana Auden and Lin-lin Zhao and Sarah D. Ellis and Pritinder Kaur and Yoshikazu Uchida and Walter M. Holleran and Peter M Elias and John M. Cunningham and Stephen M Jane},
  journal={Science},
  year={2005},
  volume={308 5720},
  pages={
          411-3
        }
}
The Drosophila cuticle is essential for maintaining the surface barrier defenses of the fly. Integral to cuticle resilience is the transcription factor grainy head, which regulates production of the enzyme required for covalent cross-linking of the cuticular structural components. We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3. Mice lacking this factor display defective skin barrier function and… CONTINUE READING
BETA

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 123 CITATIONS

Epidermal barriers.

  • Cold Spring Harbor perspectives in medicine
  • 2014
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Perturbed desmosomal cadherin expression in grainy head-like 1-null mice.

  • The EMBO journal
  • 2008
VIEW 11 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
HIGHLY INFLUENCED

Cell Biology: Master Regulators of Sealing and Healing

  • Current Biology
  • 2005
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Long-Lived Epidermal Cancer-Initiating Cells

  • International journal of molecular sciences
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2005
2019

CITATION STATISTICS

  • 18 Highly Influenced Citations

  • Averaged 9 Citations per year over the last 3 years

Similar Papers

Loading similar papers…