A history of the role of the hERG channel in cardiac risk assessment.

@article{Rampe2013AHO,
  title={A history of the role of the hERG channel in cardiac risk assessment.},
  author={David Rampe and Arthur M. Brown},
  journal={Journal of pharmacological and toxicological methods},
  year={2013},
  volume={68 1},
  pages={13-22}
}
The human ether-a-go-go-related gene (hERG, Kv11.1) K(+) channel plays an important role in cardiac repolarization. Following its cloning and expression it was established that inhibition of this channel was the molecular mechanism for many non-antiarrhythmic drugs that produce torsades de pointes associated with QT prolongation. Therefore the study of in vitro drug-hERG interactions has become an important part of modern safety pharmacology. Manual and automated patch clamp electrophysiology… CONTINUE READING
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