A history of neuraxial administration of local analgesics and opioids

@article{Brill2003AHO,
  title={A history of neuraxial administration of local analgesics and opioids},
  author={Selling Brill and G. M. Gurman and Anthony Fisher},
  journal={European Journal of Anaesthesiology},
  year={2003},
  volume={20},
  pages={682-689}
}
The history of intrathecal and epidural anaesthesia is in parallel with the development of general anaesthesia. As ether anaesthesia (1846) is considered the first modern anaesthetic since its use by Morton 157 yr ago, so Bier made history by using cocaine for intrathecal anaesthesia in 1898. The first published report on opioids for intrathecal anaesthesia belongs to a Romanian surgeon, Racoviceanu-Pitesti, who presented his experience at Paris in 1901. It was almost a century before the… 
View on Wolters Kluwer
ncbi.nlm.nih.gov
95 Citations
Highly Influential Citations
1
Background Citations
35
Methods Citations
3

95 Citations

A Clinical Approach to Neuraxial Morphine for the Treatment of Postoperative Pain
TLDR
Clinical trials have shown that epidural morphine in the form of extended-release liposome injections (EREM) gives good analgesia for a period of 48 hours, with no need for epidural catheterisation.
A Clinical Approach to Neuraxial Morphine for the Treatment of Postoperative Pain
TLDR
Clinical trials have shown that epidural morphine in the form of extended-release liposome injections (EREM) gives good analgesia for a period of 48 hours, with no need for epidural catheterisation.
Drugs 2011;
TLDR
An extensive review of articles published since 1945 that examine respiratory depression or failure associated with perioperative intrathecal or epidural morphine use finds that the optimal neuraxial opioid dose is a balance between the conflicting demands of providing optimal analgesia while minimizing dose-related adverse effects.
Neuraxial Morphine and Respiratory Depression
TLDR
An extensive review of articles published since 1945 that examine respiratory depression or failure associated with perioperative intrathecal or epidural morphine use suggests ampakine (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid [AMPA]) receptor modulators may be effective at reducing opioid-induced respiratory depression while maintaining analgesia.
Neuraxial Morphine and Respiratory Depression Finding the Right Balance
TLDR
An extensive review of articles published since 1945 that examine respiratory depression or failure associated with perioperative intrathecal or epidural morphine use finds that the optimal neuraxial opioid dose is a balance between the conflicting demands of providing optimal analgesia while minimizing dose-related adverse effects.
Spinal Opioid Bioavailability in Postoperative Pain
  • Borja Mugabure Bujedo
  • Biology, Medicine
    Pain practice : the official journal of World Institute of Pain
  • 2014
TLDR
Evidence from animal and human experiments indicates that hydrophilic opioids (such as hydromorphone and morphine) bind more strongly to specific receptors within the dorsal horn of the spinal cord than lipophilic opioids(such as alfentanil, fentanyl, and sufent anil), which means that morphine is a suitable choice for the treatment of acute postoperative pain.
Which Epidural Opioid is More Suitable for Postoperative Pain Management
TLDR
Practical information for correct spinal opioid selection is provided to help the physicians a better choice for postoperative epidural analgesia.
Postoperative analgesia with the use of lyophilized morphine
TLDR
The significant extension of analgesia with scarce demand of rescue analgesia and a stable cardiorespiratory behavior with an incidence of minor adverse effects convert anesthesia with subarachnoid Morphine into a useful and safe method for patients who have undergone either elective or emergency surgery.
Thoracic epidural anaesthesia vs intrathecal morphine in dogs undergoing major thoracic and abdominal surgery: clinical study
TLDR
TEA and ITM were effective in managing perioperative pain in dogs undergoing thoracic or cranial abdominal surgery.
Comparison of the relative analgesic efficacies of epidural or intramuscular diamorphine following total knee arthroplasty
TLDR
This study has shown the superior analgesic efficacy of epidural diamorphine when compared to intramuscular injection.
...
...

References

SHOWING 1-10 OF 46 REFERENCES
The rational use of intrathecal and extradural opioids.
  • M. Morgan
  • Medicine
    British journal of anaesthesia
  • 1989
TLDR
Pat controlled analgesia was introduced in an attempt to overcome many of these problems and has proved to be a successful method after surgery and can also be used as a method in other situations.
Intrathecal morphine as sole analgesic during labour.
TLDR
In 12 consecutive unselected patients admitted to a consultant maternity unit one single injection of subarachnoid morphine sulphate 1.5 mg abolished pain during the first stage of labour while preserving the mother's full awareness of labour and her co-operation in the second and third stages of labour.
Iatrathecd morphine for the control of the pain of myocardial infarction
TLDR
Caudally applied morphine did not relieve postoperative pain in patients who underwent haemorrhoidectomy and in the remaining 12 patients who received the caudally administered mixture of morphine and bupivacaine pain relief was 'adequate' for the test period of 24 hours.
Itching after epidural and spinal opiates
Epidural Morphine for Postoperative Pain Relief
TLDR
There was a more rapid onset of action after intramuscular morphine, however, the quality of pain relief was substantially higher and the duration of action markedly longer after epidural morphine.
ADVERSE EFFECTS OF EXTRADURAL AND INTRATHECAL OPIATES: REPORT OF A NATIONWIDE SURVEY IN SWEDEN
TLDR
Patients aged 70 yr or more, those receiving thoracic extradural puncture and those with reduced ventilatory capacity seemed to be oyerrepresented, and the administration of extradural morphine was considered as a major contributory factor for the occurrence of Ventilatory depression.
PATIENT-CONTROLLED ANALGESIA WITH EXTRADURAL MORPHINE OR PETHIDINE
TLDR
The large inter-individual variation in consumption makes it impossible to recommend a standard dose of extradural morphine or pethidine for analgesia of predictable duration and with a minimum of adverse effects.
Rostral Spread of Epidural Morphine
TLDR
Results suggest that epidural morphine travels cephalad in the cerebrospinal fluid to reach the brain stem and fourth ventricle by the sixth hour, and Hypalgesia and side effects were not related to serum concentrations of morphine.
Treatment of intrathecal morphine overdose by aspiration of cerebrospinal fluid.
TLDR
A case of intrathecal morphine overdose treated by aspiration of cerebrospinal fluid (CSF) and instillation of normal saline is described.
Eugen Bogdan Aburel (1899–1975)
TLDR
This paper described for the first time a technique of continuous epidural (caudal) and lumbo-aortic plexus block for the relief of pain in childbirth, and the principles remain valid today.
...
...