A historical perspective on leptin

  title={A historical perspective on leptin},
  author={D. Coleman},
  journal={Nature Medicine},
  • D. Coleman
  • Published 2010
  • Biology, Medicine
  • Nature Medicine
  • e-mail: doug.coleman@jax.org the db/db mutant to a normal mouse3 (Fig. 2a). After what seemed to be good wound healing and a healthy-looking parabiotic pair, I was surprised to see that the normal mouse died. My immediate thought was that I was a pretty poor surgeon, but repeated attempts consistently yielded the same outcome: only the normal mouse in the pair died. Encouraged by this stereotypic pattern, I initiated a more detailed characterization of the normal partners and found that, after… CONTINUE READING
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