A historical overview of protein kinases and their targeted small molecule inhibitors.

@article{Roskoski2015AHO,
  title={A historical overview of protein kinases and their targeted small molecule inhibitors.},
  author={Robert Roskoski},
  journal={Pharmacological research},
  year={2015},
  volume={100},
  pages={1-23}
}
Protein kinases play a predominant regulatory role in nearly every aspect of cell biology and they can modify the function of a protein in almost every conceivable way. Protein phosphorylation can increase or decrease enzyme activity and it can alter other biological activities such as transcription and translation. Moreover, some phosphorylation sites on a given protein are stimulatory while others are inhibitory. The human protein kinase gene family consists of 518 members along with 106… CONTINUE READING