A historical and evolutionary perspective on the biological significance of circulating DNA and extracellular vesicles

@article{Aucamp2016AHA,
  title={A historical and evolutionary perspective on the biological significance of circulating DNA and extracellular vesicles},
  author={Janine Aucamp and Abel Jacobus Bronkhorst and Christoffel P. S. Badenhorst and Piet J. Pretorius},
  journal={Cellular and Molecular Life Sciences},
  year={2016},
  volume={73},
  pages={4355-4381}
}
The discovery of quantitative and qualitative differences of the circulating DNA (cirDNA) between healthy and diseased individuals inclined researchers to investigate these molecules as potential biomarkers for non-invasive diagnosis and prognosis of various pathologies. However, except for some prenatal tests, cirDNA analyses have not been readily translated to clinical practice due to a lack of knowledge regarding its composition, function, and biological and evolutionary origins. We believe… 
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