A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR.

@article{Dhillon2000AHV,
  title={A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR.},
  author={Namrita Dhillon and Rohinton T. Kamakaka},
  journal={Molecular cell},
  year={2000},
  volume={6 4},
  pages={
          769-80
        }
}
Silencing at HMR requires silencers, and one of the roles of the silencer is to recruit Sir proteins. This work focuses on the function of Sir1p once it is recruited to the silencer. We have generated mutants of Sir1p that are recruited to the silencer but are unable to silence, and we have utilized these mutants to identify four proteins, Sir3p, Sir4p, Esc2p, and Htz1p, that when overexpressed, restored silencing. The isolation of Sir3p and Sir4p validated this screen. Molecular analysis… Expand

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