A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb.

@article{Pengelly2013AHM,
  title={A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb.},
  author={Ana Raquel Pengelly and {\"O}mer Utku Çopur and Herbert Jaeckle and Alf Herzig and J{\"u}rg M{\"u}ller},
  journal={Science},
  year={2013},
  volume={339 6120},
  pages={698-9}
}
Although many metazoan enzymes that add or remove specific modifications on histone proteins are essential transcriptional regulators, the functional significance of posttranslational modifications on histone proteins is not well understood. Here, we show in Drosophila that a point mutation in lysine 27 of histone H3 (H3-K27) fails to repress transcription of genes that are normally repressed by Polycomb repressive complex 2 (PRC2), the methyltransferase that modifies H3-K27. Moreover… CONTINUE READING
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