A histone H3 lysine 27 demethylase regulates animal posterior development

@article{Lan2007AHH,
  title={A histone H3 lysine 27 demethylase regulates animal posterior development},
  author={Fei Lan and Peter E Bayliss and John L. Rinn and Johnathan R. Whetstine and Jordon K. Wang and Shuzhen Chen and Shigeki Iwase and Roman Alpatov and Irina Issaeva and Eli Canaani and Thomas M. Roberts and Howard Y. Chang and Yang Shi},
  journal={Nature},
  year={2007},
  volume={449},
  pages={689-694}
}
The recent discovery of a large number of histone demethylases suggests a central role for these enzymes in regulating histone methylation dynamics. Histone H3K27 trimethylation (H3K27me3) has been linked to polycomb-group-protein-mediated suppression of Hox genes and animal body patterning, X-chromosome inactivation and possibly maintenance of embryonic stem cell (ESC) identity. An imbalance of H3K27 methylation owing to overexpression of the methylase EZH2 has been implicated in metastatic… 

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