A highly tilted membrane configuration for the prefusion state of synaptobrevin.

@article{Blanchard2014AHT,
  title={A highly tilted membrane configuration for the prefusion state of synaptobrevin.},
  author={Andrew E. Blanchard and Mark J. Arcario and Klaus Schulten and Emad Tajkhorshid},
  journal={Biophysical journal},
  year={2014},
  volume={107 9},
  pages={2112-21}
}
The SNARE complex plays a vital role in vesicle fusion arising during neuronal exocytosis. Key components in the regulation of SNARE complex formation, and ultimately fusion, are the transmembrane and linker regions of the vesicle-associated protein, synaptobrevin. However, the membrane-embedded structure of synaptobrevin in its prefusion state, which determines its interaction with other SNARE proteins during fusion, is largely unknown. This study reports all-atom molecular-dynamics… CONTINUE READING

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