A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC

@inproceedings{Sethi2011AHT,
  title={A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC},
  author={Dhruv K. Sethi and David A. Schubert and A. Anders and Annie H{\'e}roux and Daniel A. Bonsor and Chantz P. Thomas and Eric J Sundberg and Jason W Pyrdol and Kai W Wucherpfennig},
  booktitle={The Journal of experimental medicine},
  year={2011}
}
Self-reactive T cells that escape elimination in the thymus can cause autoimmune pathology, and it is therefore important to understand the structural mechanisms of self-antigen recognition. We report the crystal structure of a T cell receptor (TCR) from a patient with relapsing-remitting multiple sclerosis that engages its self-peptide-major histocompatibility complex (pMHC) ligand in an unusual manner. The TCR is bound in a highly tilted orientation that prevents interaction of the TCR… CONTINUE READING

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