A highly stable covalent conjugated heparin biochip for heparin-protein interaction studies.

@article{Zhang2002AHS,
  title={A highly stable covalent conjugated heparin biochip for heparin-protein interaction studies.},
  author={Fuming Zhang and Melissa A. Fath and R. M. Marks and Robert J. Linhardt},
  journal={Analytical biochemistry},
  year={2002},
  volume={304 2},
  pages={271-3}
}
Heparin is a proteoglycan composed of highly sulfated linear polysaccharides of alternating uronic acid and glucosamine that interacts with a wide variety of proteins and peptides (1). Heparin and the structurally related heparan sulfate are the most acidic polysaccarides in the human body and, as a result, interact with many cationic proteins, giving rise to myriad biological activities (2). Some of these interactions have received extensive attention in recent years, including heparin’s… CONTINUE READING