A highly specific benzimidazole pyridazinone reverses phosphate-induced changes in cardiac myofilament activation.

@article{Westfall1993AHS,
  title={A highly specific benzimidazole pyridazinone reverses phosphate-induced changes in cardiac myofilament activation.},
  author={Margaret V. Westfall and Gordon M. Wahler and R. John Solaro},
  journal={Biochemistry},
  year={1993},
  volume={32 39},
  pages={10464-70}
}
Both Ca2+ and the actin cross-bridge reaction itself can activate contraction in myofilaments. We are interested in identifying ligands which modify one or both mechanisms of contractile activation with high affinity and specificity. Results presented here suggest that the benzimidazole-substituted pyridazinone, UD-CG 212 Cl, potently modulates myofilament activation by the cross-bridge reaction. Cross-bridge-mediated activation was studied by varying the population of force-generating (strong… CONTINUE READING