A highly sensitive immunoassay resistant to autoantibody interference for detection of the diabetes-associated autoantigen glutamic acid decarboxylase 65 in blood and other biological samples.

@article{Waldrop2006AHS,
  title={A highly sensitive immunoassay resistant to autoantibody interference for detection of the diabetes-associated autoantigen glutamic acid decarboxylase 65 in blood and other biological samples.},
  author={Megan A Waldrop and Arthur T. Suckow and Tyler R. Hall and Chris S. Hampe and Santica M. Marcovina and Steven D Chessler},
  journal={Diabetes technology & therapeutics},
  year={2006},
  volume={8 2},
  pages={
          207-18
        }
}
BACKGROUND Glutamic acid decarboxylase-65 (GAD65) is a major autoantigen in autoimmune diabetes and is discharged from injured islet beta cells. GAD65 may also be released by transplanted islets undergoing immunological rejection. To test hypotheses regarding the utility of GAD65 as a biomarker for transplant rejection or diabetes-associated islet damage and also regarding the timing and instigators of GAD65 release in humans or animal models, a sensitive assay capable of measuring GAD65 in… CONTINUE READING
BETA