A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice.

@article{Mcintyre2003AHS,
  title={A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice.},
  author={Kim W Mcintyre and David J. Shuster and Kathleen M. Gillooly and Donna M Dambach and Mark A. Pattoli and Pin Lu and Xia-di Zhou and Yuping Qiu and F. Christopher Zusi and James R Burke},
  journal={Arthritis and rheumatism},
  year={2003},
  volume={48 9},
  pages={2652-9}
}
OBJECTIVE The transcription of several cytokines, cell adhesion molecules, and enzymes involved in the inflammatory and destructive mechanisms of rheumatoid arthritis is dependent on nuclear factor kappa B (NF-kappa B). Because I kappa B kinase (IKK) is critical in transducing the signal-inducible activation of NF-kappa B, we examined whether the highly selective and orally bioavailable IKK inhibitor BMS-345541 is efficacious against collagen-induced arthritis (CIA) in mice. METHODS Arthritis… CONTINUE READING

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