A highly selective fluorescent probe for Fe3+ in living cells: a stress induced cell based model study.

@article{Sharma2017AHS,
  title={A highly selective fluorescent probe for Fe3+ in living cells: a stress induced cell based model study.},
  author={Neetu Sharma and Shahi Imam Reja and Neha Gupta and Vandana Bhalla and Davinder Kaur and Saroj Arora and Manoj Kumar},
  journal={Organic \& biomolecular chemistry},
  year={2017},
  volume={15 4},
  pages={
          1006-1012
        }
}
A rhodamine-phenanthroline dyad based fluorescent probe 4 has been designed and synthesized which selectively monitors Fe3+ ions among the various metal ions tested. Furthermore, probe 4 has been explored for monitoring of dynamic changes in the Fe3+ ion level under aggressive Fenton reaction conditions using a cell based model study. More significantly, probe 4 has also been utilized for real time imaging of endogenous Fe3+ ions in living C6 cell lines, the results of which demonstrated that… 
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19 Citations

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References

SHOWING 1-10 OF 45 REFERENCES
Selective off-on fluorescent chemosensor for detection of Fe3+ ions in aqueous media.
A Fe(3+) chemosensor L1 was successfully synthesized with a quinoline moiety bound to rhodamine 6G hydrazide. The sensor L1 shows high selectivity and sensitivity to Fe(3+) in aqueous solution in the…
Rhodamine based fluorescence turn-on chemosensor for nanomolar detection of Fe3+ ions
FRET-based fluorescence ratiometric and colorimetric sensor to discriminate Fe3+ from Fe2+
A benzothiazole conjugated quinoline derivative appended with rhodamine-6G acts as an efficient FRET-based single molecular switch for Fe3+. The structure of the probe was confirmed through its…
A Turn‐on Fluorescent Sensor for Imaging Labile Fe3+ in Live Neuronal Cells at Subcellular Resolution
TLDR
The sensor can respond to changes in intracellular Fe(3+) levels and was used to image endogenous chelatable Fe( 3+) in live human neuroblastoma SH-SY5Y cells, with two Fe(2+) pools being identified in mitochondria and endosomes/ lysosomes for the first time.
Orientation effect induced selective chelation of Fe2+ to a glutamic acid appended conjugated polymer for sensing and live cell imaging.
TLDR
A water soluble polymer based probe for the fluorescence sensing and live cell imaging of labile Fe2+ ions with high selectivity for the first time and exhibited improved sensing activity in the range of intracellular pH (5-9) which is advantageous in differentiating endogenous changes.
A highly selective fluorescent probe for hypochlorite and its endogenous imaging in living cells.
An oxime based fluorescent probe has been designed and synthesized, which detects free as well as enzymatically generated hypochlorite with a low detection limit and high sensitivity. In addition,…
Self-Assembly of Fluorescent Organic Nanoparticles for Iron(III) Sensing and Cellular Imaging.
TLDR
Novel fluorescent organic nanoparticles via facile self-assembly method in aqueous solution exhibit high sensitivity and selectivity toward Fe(3+) sensing with detection limit of 0.1 nM and are capable of Fe( 3+) sensing via fluorescence quenching in cellular environment.
Molecular imaging of labile iron(II) pools in living cells with a turn-on fluorescent probe.
TLDR
This first-generation chemical tool for fluorescence Fe(2+) detection can visualize changes in exchangeable iron stores in living cells upon iron supplementation or depletion, including labile iron pools at endogenous, basal levels.
A dual colorimetric-ratiometric fluorescent probe NAP-3 for selective detection and imaging of endogenous labile iron(III) pools in C. elegans.
TLDR
The first dual colorimetric and ratiometric fluorescent probe naphtho[2,1-b][1,10]phenanthroline for selective and 'direct' visualization of labile iron(III) pools in a multicellular organism, Caenorhabditis elegans is reported.
Synthetic fluorescent sensors for studying the cell biology of metals.
TLDR
A review of available synthetic small-molecule sensor types for fluorescence detection of cellular metals presents a host of emerging opportunities for visualizing, in real time, aspects of metal accumulation, trafficking, and function or toxicity in living systems.
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