A highly selective and specific PET tracer for imaging of tau pathologies.

  title={A highly selective and specific PET tracer for imaging of tau pathologies.},
  author={Wei Zhang and Janna Arteaga and Daniel K Cashion and Gang Chen and Umesh B Gangadharmath and Luis Felipe Gomez and Dhanalakshmi Kasi and Chung Lam and Qianwa Liang and Changhui Liu and Vani P. Mocharla and Fanrong Mu and Anjana Sinha and Anna Katrin Szardenings and Eric Shing-Suan Wang and Joseph C. Walsh and Chunfang Xia and Chul H Yu and Tieming Zhao and Hartmuth C. Kolb},
  journal={Journal of Alzheimer's disease : JAD},
  volume={31 3},
Senile plaques and neurofibrillary tangles are prominent neuropathological hallmarks in Alzheimer's disease and are considered to be targets for therapeutic intervention as well as biomarkers for diagnostic in vivo imaging agents. While there are a number of amyloid-β positron emission tomography (PET) tracers currently in different stages of clinical development and commercialization, there have been very few reports on imaging agents selectively targeting tau aggregates. In search of [18F… CONTINUE READING
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