A highly recurrent RPS27 5'UTR mutation in melanoma

  title={A highly recurrent RPS27 5'UTR mutation in melanoma},
  author={Ken Dutton-Regester and Jared J. Gartner and Rafi Emmanuel and Nouar Qutob and Michael A. Davies and Jeffrey E Gershenwald and William A. Robinson and Steven E. Robinson and Steven A Rosenberg and Richard A Scolyer and Graham J. Mann and J. J. Thompson and N. K. Hayward and Yardena Samuels},
The incidence of melanoma continues to rise globally and is increasing at a rate greater than any other cancer. To systematically search for new genes involved in melanomagenesis, we collated exome sequencing data from independent melanoma cohort datasets, including those in the public domain. We identified recurrent mutations that may drive melanoma growth, survival or metastasis, and which may hold promise for the design of novel therapies to treat melanoma. These included a frequent… CONTINUE READING
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