A highly prevalent and genetically diversified Picornaviridae genus in South Asian children.

  title={A highly prevalent and genetically diversified Picornaviridae genus in South Asian children.},
  author={Amit Kapoor and Joseph Victoria and Peter Simmonds and Elizabeth Slikas and Thaweesak Chieochansin and Asif Naeem and Shahzad Shaukat and Salmaan Sharif and Muhammad Masroor Alam and Mehar Angez and Chunlin Wang and Robert W. Shafer and Syed Sohail Zahoor Zaidi and Eric L Delwart},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 51},
Viral metagenomics focused on particle-protected nucleic acids was used on the stools of South Asian children with nonpolio acute flaccid paralysis (AFP). We identified sequences distantly related to Seneca Valley virus and cardioviruses that were then used as genetic footholds to characterize multiple viral species within a previously unreported genus of the Picornaviridae family. The picornaviruses were detected in the stools of >40% of AFP and healthy Pakistani children. A genetically… CONTINUE READING
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