A highly enantioselective synthesis of (R)-salmeterol using a chiral auxiliary

  title={A highly enantioselective synthesis of (R)-salmeterol using a chiral auxiliary},
  author={Li-Jiao Jiang and Chenggang Lin and Yi-Feng Qiu and Xu Quan and Jing Zhu and Haijian Shi},
  journal={Journal of Chemical Research},
  pages={564 - 566}
A facile strategy for enantioselective synthesis of (R)-salmeterol is described via a chiral auxiliary starting from 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone through four or five steps. The product was obtained in good purity, enantiomeric excess and yield. 
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