A highly enantioselective four-component reaction for the efficient construction of chiral β-hydroxy-α-amino acid derivatives.

@article{Qian2013AHE,
  title={A highly enantioselective four-component reaction for the efficient construction of chiral $\beta$-hydroxy-$\alpha$-amino acid derivatives.},
  author={Yu Qian and Changcheng Jing and Shunying Liu and Wenhao Hu},
  journal={Chemical communications},
  year={2013},
  volume={49 26},
  pages={
          2700-2
        }
}
An enantioselective four-component reaction of a diazoketone, water, an aniline and ethyl glyoxylate in the presence of catalytic Rh2(OAc)4 and a chiral Brønsted acid was developed to efficiently produce β-hydroxy-α-amino acid derivatives in good yields with high diastereoselectivity and enantioselectivity. 
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32 Citations

32 Citations

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