A highly enantioselective four-component reaction for the efficient construction of chiral β-hydroxy-α-amino acid derivatives.

  title={A highly enantioselective four-component reaction for the efficient construction of chiral $\beta$-hydroxy-$\alpha$-amino acid derivatives.},
  author={Yu Qian and Changcheng Jing and Shunying Liu and Wenhao Hu},
  journal={Chemical communications},
  volume={49 26},
An enantioselective four-component reaction of a diazoketone, water, an aniline and ethyl glyoxylate in the presence of catalytic Rh2(OAc)4 and a chiral Brønsted acid was developed to efficiently produce β-hydroxy-α-amino acid derivatives in good yields with high diastereoselectivity and enantioselectivity. 
32 Citations

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