A highly efficient macrolactonization method via ethoxyvinyl ester.

@article{Ohba2009AHE,
  title={A highly efficient macrolactonization method via ethoxyvinyl ester.},
  author={Yusuke Ohba and Mayuko Takatsuji and Kenji Nakahara and H. Fujioka and Y. Kita},
  journal={Chemistry},
  year={2009},
  volume={15 14},
  pages={
          3526-37
        }
}
We present the highly efficient reaction procedure of the macrolactonization method via ethoxyvinyl esters (EVEs). The following procedure was performed: 1) The EVE was prepared from hydroxycarboxylic acid and ethoxyacetylene in the presence of the Ru catalyst [RuCl(2)(p-cymene)](2) in acetone; 2) after filtration of the Ru catalyst through a short-neutral SiO(2) pad and evaporation of acetone, the EVE formed was diluted in 1,2-dichloroethane (DCE) and the solution was slowly added by a syringe… Expand
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