A highly efficient and direct approach for synthesis of enantiopure beta-amino alcohols by reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes.

@article{Zhong2005AHE,
  title={A highly efficient and direct approach for synthesis of enantiopure beta-amino alcohols by reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes.},
  author={Yuwu Zhong and Yi-Zhou Dong and Kai Fang and Kenji Izumi and Ming-Hua Xu and Guo-qiang Lin},
  journal={Journal of the American Chemical Society},
  year={2005},
  volume={127 34},
  pages={11956-7}
}
A highly efficient and practical approach for the synthesis of optically pure beta-amino alcohols by the SmI2-induced reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes was developed. This method allows the preparation of a broad range of chiral beta-amino alcohols, including functionalized ones under mild conditions. It provides a straightforward access to enantiopure beta-amino alcohols that are widely applicable in asymmetric synthesis. 

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