A highly effective, nontoxic T1 MR contrast agent based on ultrasmall PEGylated iron oxide nanoparticles.

@article{Tromsdorf2009AHE,
  title={A highly effective, nontoxic T1 MR contrast agent based on ultrasmall PEGylated iron oxide nanoparticles.},
  author={Ulrich I Tromsdorf and Oliver T Bruns and Sunhild C Salmen and Ulrike Beisiegel and Horst Weller},
  journal={Nano letters},
  year={2009},
  volume={9 12},
  pages={4434-40}
}
In this study we systematically developed a potential MR T(1) contrast agent based on very small PEGylated iron oxide nanoparticles. We adjusted the size of the crystalline core providing suitable relaxometric properties. In addition, a dense and optimized PEG coating provides high stability under physiological conditions together with low cytotoxicity and low nonspecific phagocytosis into macrophage cells as a part of the reticulo endothelial system at biologically relevant concentrations. The… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.

Contrast Agents I

  • E. Toth, L. Helm, A. E. Merbach
  • Eur. Radiol
  • 2001

Similar Papers

Loading similar papers…