A highly divergent microsatellite facilitating fast and accurate DRB haplotyping in humans and rhesus macaques.

@article{Doxiadis2007AHD,
  title={A highly divergent microsatellite facilitating fast and accurate DRB haplotyping in humans and rhesus macaques.},
  author={Gaby G. M. Doxiadis and Nanine de Groot and Frans H. J. Claas and Ilias I. N. Doxiadis and Jon J. van Rood and Ronald Bontrop},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 21},
  pages={8907-12}
}
The DRB region of the MHC in primate species is known to display abundant region configuration polymorphism with regard to the number and content of genes present per haplotype. Furthermore, depending on the species studied, the different DRB genes themselves may display varying degrees of allelic polymorphism. Because of this combination of diversity (differential gene number) and polymorphism (allelic variation), molecular typing methods for the primate DRB region are cumbersome. All intact… CONTINUE READING

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