A highly conserved sequence essential for translational repression of the protamine 1 messenger rna in murine spermatids.

@article{Zhong2001AHC,
  title={A highly conserved sequence essential for translational repression of the protamine 1 messenger rna in murine spermatids.},
  author={Jun Wen Zhong and Antoine H. F. M. Peters and Karen Kafer and Robert E Braun},
  journal={Biology of reproduction},
  year={2001},
  volume={64 6},
  pages={1784-9}
}
Translational regulation of the protamine 1 mRNA is mediated by sequences in its 3' untranslated region. In this study, we demonstrate that a highly conserved sequence, the translational control element, is solely responsible for protamine 1 translational regulation. Mutation of the conserved sequence causes premature translation of a transgene containing a fusion between the human growth hormone coding sequence and the protamine 1 3' untranslated region. Temporal expression of the transgene… CONTINUE READING
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