A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead

@article{Wilanowski2002AHC,
  title={A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead},
  author={Tomasz Wilanowski and Annabel Tuckfield and Loretta Cerruti and Sinead O'Connell and Robert E. Saint and Vishwas Parekh and Jianning Tao and John M. Cunningham and Stephen M Jane},
  journal={Mechanisms of Development},
  year={2002},
  volume={114},
  pages={37-50}
}
The Drosophila transcription factor Grainyhead regulates several key developmental processes. Three mammalian genes, CP2, LBP-1a and LBP-9 have been previously identified as homologues of grainyhead. We now report the cloning of two new mammalian genes (Mammalian grainyhead (MGR) and Brother-of-MGR (BOM)) and one new Drosophila gene (dCP2) that rewrite the phylogeny of this family. We demonstrate that MGR and BOM are more closely related to grh, whereas CP2, LBP-1a and LBP-9 are descendants of… CONTINUE READING