A highly conserved molecular switch binds MSY-3 to regulate myogenin repression in postnatal muscle.

@article{Berghella2008AHC,
  title={A highly conserved molecular switch binds MSY-3 to regulate myogenin repression in postnatal muscle.},
  author={Libera Berghella and Luciana de Angelis and Tristan De Buysscher and Ali M. Mortazavi and Stefano Biressi and Sonia Vanina Forcales and Dario Sirabella and Giulio Cossu and Barbara J. Wold},
  journal={Genes & development},
  year={2008},
  volume={22 15},
  pages={2125-38}
}
Myogenin is the dominant transcriptional regulator of embryonic and fetal muscle differentiation and during maturation is profoundly down-regulated. We show that a highly conserved 17-bp DNA cis-acting sequence element located upstream of the myogenin promoter (myogHCE) is essential for postnatal repression of myogenin in transgenic animals. We present multiple lines of evidence supporting the idea that repression is mediated by the Y-box protein MSY-3. Electroporation in vivo shows that… CONTINUE READING

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