A highly catalytically active γ-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules.

@article{Prete2013AHC,
  title={A highly catalytically active γ-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules.},
  author={Sonia Del Prete and Daniela Vullo and Viviana De Luca and Vincenzo Carginale and Andrea Scozzafava and Claudiu T. Supuran and Clemente Capasso},
  journal={Bioorganic & medicinal chemistry letters},
  year={2013},
  volume={23 14},
  pages={4067-71}
}
Carbonic anhydrases (CAs, EC 4.2.1.1) belonging to the γ-class are present in archaea, bacteria and plants but, except the Methanosarcina thermophila enzymes CAM and CAMH, they were poorly characterized so far. Here we report a new such enzyme (PgiCA), the γ-CA from the oral cavity pathogenic bacterium Porphyromonas gingivalis, the main causative agent of periodontitis. PgiCA showed a good catalytic activity for the CO2 hydration reaction, comparable to that of the human (h) isoform hCA I… CONTINUE READING
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