A highly active homeobox gene promoter regulated by Ets and Sp1 family members in normal granulosa cells and diverse tumor cell types.

@article{Rao2002AHA,
  title={A highly active homeobox gene promoter regulated by Ets and Sp1 family members in normal granulosa cells and diverse tumor cell types.},
  author={Manjeet K. Rao and Sourindra Maiti and Honnavara N. Ananthaswamy and Miles F. Wilkinson},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 29},
  pages={26036-45}
}
One mechanism by which normal cells become converted to tumor cells involves the aberrant transcriptional activation of genes that are normally silent. We characterize a promoter that normally exhibits highly tissue- and stage-specific expression but displays ubiquitous expression when cells become immortalized or malignant, regardless of their lineage or tissue origin. This promoter normally drives the expression of the Pem homeobox gene in specific cell types in ovary and placenta but is… CONTINUE READING

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