A higher maternal choline intake among third-trimester pregnant women lowers placental and circulating concentrations of the antiangiogenic factor fms-like tyrosine kinase-1 (sFLT1).

@article{Jiang2013AHM,
  title={A higher maternal choline intake among third-trimester pregnant women lowers placental and circulating concentrations of the antiangiogenic factor fms-like tyrosine kinase-1 (sFLT1).},
  author={Xinyin Jiang and Haim Bar and Jian Yan and Sara Jones and Patsy M. Brannon and Allyson A. West and Cydne A. Perry and Anita Ganti and Eva K. Pressman and Srisatish Devapatla and Francoise Vermeylen and Martin T. Wells and Marie A. Caudill},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2013},
  volume={27 3},
  pages={1245-53}
}
This study investigated the influence of maternal choline intake on the human placental transcriptome, with a special interest in its role in modulating placental vascular function. Healthy pregnant women (n=26, wk 26-29 gestation) were randomized to 480 mg choline/d, an intake level approximating the adequate intake of 450 mg/d, or 930 mg/d for 12 wk… CONTINUE READING