A higher frequency of CD4⁺CXCR5⁺ T follicular helper cells in patients with newly diagnosed IgA nephropathy.

@article{Zhang2014AHF,
  title={A higher frequency of CD4⁺CXCR5⁺ T follicular helper cells in patients with newly diagnosed IgA nephropathy.},
  author={Li Zhang and Yingying Wang and Xu Shi and Hongbin Zou and Yanfang Jiang},
  journal={Immunology letters},
  year={2014},
  volume={158 1-2},
  pages={101-8}
}
The frequency of different subsets of CD4(+)CXCR5(+) TFH cells and the levels of serum cytokines were examined in 24 patients with newly diagnosed IgAN before and 8-12 weeks after treatment and in 12 healthy controls (HC). In comparison with HC, significantly higher percentages of CD4(+)CXCR5(+), CD4(+)CXCR5(+)ICOS(+), CD4(+)CXCR5(+)PD-1(+) TFH cells and higher levels of serum IL-17A, IFN-γ, IL-2, IL-10, IL-4 and IL-21 were detected in IgAN patients. The percentages of CD4(+)CXCR5(+) TFH cells… CONTINUE READING

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